Abstract Recently, the University of California, Los Angeles (UCLA) Dental College has greatly improved the treatment of root canal treatment with artificial nano-diamonds, which has brought good news to patients with dental diseases. The study was published in the journal ACSNano. Nano gold
Recently, the University of California, Los Angeles (UCLA) Dental College has greatly improved the treatment of root canal treatment with artificial nano-diamonds, which has brought good news to patients with dental diseases. 
In the United States, more than 15 million patients receive root canal treatment each year to prevent dental pulp infection. The pulp is part of the tooth, including blood vessels and nerve tissue. In the process of root canal treatment, the infected pulp should be removed, and the space inside the tooth is filled with eucommia gel polymer material. Eucommia gum is not easy to react with dental tissues, so it is often used as a filling material for root canal treatment. If the infected pulp is not completely removed, the residual part will infect the entire tooth and cause the tooth to fall off.
However, eucommia gum polymer materials also have some defects, such as insufficient resistance to tooth infection and low hardness.
To overcome these technical deficiencies, the UCLA team tested two enhanced gutta-percha products: one is nano-diamond-reinforced gutta-percha, and the other is nano-diamond-reinforced gutta-percha, pre-loaded with antibiotics.
To test the performance of the first gutta-percha, Sue Vin Kim and Adelheid Nerisa Limansubroto were filled with nano-diamond gutta percha in the patient's teeth. With X-ray photography and CT, the staff found that there were still gaps in the filled teeth, which is the main cause of bacterial infection in the later stages of dental treatment. CT imaging proves that the effect of this reinforced material on filling teeth is the same as that of traditional gutta percha.
In the second phase of the experiment, the staff used a nanodiamond-reinforced gutta-percha gel preloaded with a broad-spectrum antibiotic, amoxicillin. The experimental results show that the combination of the drug-enhanced nano-diamond and eucommia gum can effectively prevent bacterial growth and dental infection.
Dr. Dong-Keun Lee, a postdoctoral fellow in the laboratory, said that the drug-resistant nano-diamond-reinforced eucommia gum combines many superior properties, enhancing the hardness of the root canal filling material and preventing bacterial infection.
This new dental technology combines materials science, nanotechnology, drug delivery, toxicology, oral radiology, endodontics and microbiology, and is transforming existing dental development technologies in the future. There are broad prospects in clinical trials.
The study was supported by the National Cancer Institute, the National Science Foundation, the Wallace H. Coulter Foundation, the Cancer Research Foundation, and the Beckman Coulter Life Sciences Institute.
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