Recently, the radiation biomedical research center of the Medical Physics and Technology Center of the Chinese Academy of Sciences' Hefei Institute of Material Science has made new progress in the regulation of carbon monoxide on paramagnetic effects in the three-dimensional cell model. The research results were published in the "International Journal of Molecular Science, 2016: 17(12), 2051) titled Low Concentration of Exogenous Carbon Monoxide Modulates Radiation-Induced Bystander Effect in Mammalian Cell Cluster Mode.
In long-term radiation therapy, primary radiation outside the irradiated area is likely to induce the occurrence of secondary cancer and is the enemy of health for survivors. The bystander effect of radiation is believed to be closely related to the occurrence of this second cancer. After being exposed to radiation, the cells release side effect signals, which are transmitted to the vicinity even at a long distance, resulting in cell proliferation, genetic material damage and gene mutation until tumors form. Low concentration of carbon monoxide is an important signal regulator in the body, which has a wide range of clinical value. Previous studies in the Radiation Biomedical Research Laboratory have confirmed that in a two-dimensional culture of cells, low concentrations of carbon monoxide can protect paracrine cells from damage signals. The two-dimensional cell model serves as a monolayer, simplified culture system in which the physiological state of the cells and the ability to respond to external stimuli are quite different from those in vivo. The three-dimensional tissue is closer to the actual physiological conditions.
In a three-dimensional cell model, the researchers conducted a study on the regulation of the paramagnetic effects of carbon monoxide at low concentrations. The results showed that the low concentration of carbon monoxide was effective in the regulation of radiation bystander effect, and the regulation effect was concentration-dependent. CORM-2 as low as 30 μM could effectively protect the paracellular cells and effectively reduce DNA double-strand breaks, micronuclei and cell proliferation to The background level and mechanism study showed that the low concentration of carbon monoxide significantly reduced the expression levels of key signaling molecules (iNOS and COX-2) in the side effect signalling pathway and thus regulated the transmission of radiation bystander effects. The results of this study provide experimental evidence and theoretical guidance for potential clinical applications of carbon monoxide.
The research work was supported by projects supported by the National Natural Science Foundation of China, the Natural Science Foundation of Anhui Province, and the Hefei Material Science and Technology Center.
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